Betty is the aunt of Howard Joel Wolowitz and may be the sister of either Sam Wolowitz or Debbie Melvina Wolowitz (but most likely of the latter). She and her husband Elliot are coming from Palm Springs, California for dinner at the Wolowitz House to supposedly meet Howard's girlfriend, Dr. Stephanie Barnett though Stephanie is not interested. By Howard's marriage, she became an aunt-in-law to Bernadette Maryann Rostenkowski-Wolowitz. The result of such union has led to her becoming a great-aunt to Halley Wolowitz.
- Probably the sister of Debbie since Howard mentioned in "The Cohabitation Formulation" that his mom was going to Palm Springs to visit her sister.