Edna is an aunt of Leonard Hofstadter, Michael Hofstadter and their sister. Leonard tells Sheldon and Leslie Winkle that Edna is one of the hairiest women they'd ever meet. He also mentions that she's a sweet lady and when she hugs him, he's tickled.
- Brother or ex-brother-in-law: Alfred Hofstadter
- Sister or ex-sister-in-law: Beverly Hofstadter
- Nephews: Leonard Hofstadter, Michael Hofstadter
- Niece: Unnamed
- Niece-in-Law: Penny Hofstadter née ?
- Possible Niece-in-Law: Unnamed
- Nephew-in-Law: Unnamed
- Possible Father: Unnamed
- Possible Mother: Unnamed
- Possible Brother/Husband: Floyd
- Possible Sisters: Nancy, Unnamed
- Possible Children: Unnamed