Claire first appears in "The Meemaw Materialization", she meets Raj and Howard at the comic book store and tells them she is writing for a children's science fiction movie script and wants to collaborate with Raj. She is only interested in his help while Raj has visions of marriage and children.
After he breaks up with Emily in the next episode ("The Valentino Submergence"), he wants to see her on Valentine's Day; however, she just got back together with her boyfriend. She also thinks that he's an ass for breaking up with Emily just before the lover's holiday.
Later, in "The Application Deterioration", Claire calls him back to tell him that she broke up again with her boyfriend. Raj must now make a decision when he also gets a call from Emily, who misses him. Claire says that Emily is trying to manipulate him, but Raj visits Emily and they end up in bed together.
Later, in "The Fermentation Bifurcation", Raj claims to be dating two women and Claire is seen going to a wine tasting with him and the gang, excluding Sheldon and Bernadette. Claire doesn't seem happy about the fact that Raj is seeing two women at once and at the wine tasting, she almost gets hit on by Zack whom Raj stops when he tells him that Claire is with him.
In "The Hot Tub Contamination", Raj admits that he has broken up with both girls at the ladies' insistence, so he is no longer seeing Claire.
She has reappeared in "The Emotion Detection Automation", along with Emily (season 5), Lucy, and Emily. Claire broke up with him because she found him extremely needy and vain. Also she found what she wanted in a guy after dating Raj.
- Like Stuart, Alex and Priya before her, she may just be a tool to make another character see how much he/she feels for his/her regular significant other.
- The fact that Claire is a blonde woman who's a bartender and screenwriter makes her very similar to Penny, who worked as a waitress/bartender, wrote a screenplay, and is/was an actress.
- Steven Molaro teased that Emily and Claire could be back in season 10., which was confirmed when they both returned in "The Emotion Detection Automation" (S10E14).
- After she and Raj broke up, she got a new boyfriend.