Family Guy is an adult animated sitcom created by Seth MacFarlane for the Fox Broadcasting Company mentioned by Howard.
Connection with The Big Bang TheorySheldon and Leonard voiced by Jim Parsons and Johnny Galecki in Business Guy. Penny appears, but does not speak.
In the Family Guy episode,  Business Guy, Peter tells Carter to have a viewing party for The Big Bang Theory. In this parody, Sheldon tells Leonard that he can "bench press" 690 billion nanograms, prompting Leonard to remind him that that is the equivalent of up to 2 pounds (690 000 000 000 ng < 2 lbs).