Leonard Nimoy is an American actor best known for playing the half-Vulcan Spock on Star Trek in movies and on television. Sheldon is very obsessed with Nimoy as a result of his obsession of Spock.

In "The Bath Item Gift Hypothesis", Penny got a napkin signed by Leonard Nimoy when he visited the Cheesecake Factory and when Sheldon found out that it had a stain from Nimoy, he was beyond excited because he had his DNA and could make Leonard Nimoy clones.

In "The Excelsior Acquisition", Sheldon revealed that he had a restraining order from Leonard Nimoy after receiving a restraining order from Stan Lee.

In "The Transporter Malfunction", Nimoy voiced a Spock action-figure who convinced Sheldon to use his transporter, then shunned him for replacing it with Leonard's after he broke his own.