This woman is the mother of either Alfred Hofstadter or Beverly Hofstadter and the grandmother of Leonard Hofstadter, Michael Hofstadter and their sister. She suffers from Alzheimer's and stripped naked one Thanksgiving in Sheldon Cooper and Leonard Hoffstadter's apartment.
- Son or ex-son-in-law: Alfred Hofstadter
- Daughter or ex-daughter-in-law: Beverly Hofstadter
- Grandsons: Leonard Hofstadter, Michael Hofstadter
- Granddaughter: Unnamed
- Granddaughter-in-Law: Penny Hofstadter née ?
- Possible Granddaughter-in-Law: Unnamed
- Grandson-in-Law: Unnamed
- Possible Husband: Unnamed
- Possible Son: Floyd
- Possible Daughters: Edna, Nancy, Unnamed
- Possible Grandchildren: Unnamed