This page lists the Main Characters on The Big Bang Theory whose names have appeared during the opening credits currently or in the past.
Leonard Hofstadter is the best friend and former roommate of Sheldon Cooper, husband of Penny Hofstadter, and he works as an experimental physicist doing research at the California Institute of Technology with Sheldon, Howard, and Raj. Leonard is portrayed by Johnny Galecki.
Sheldon Cooper is Leonard Hofstadter's best friend and former roommate, Amy Farrah Fowler's husband and he works as a theoretical physicist doing research at the California Institute of Technology with Leonard, Raj, and Howard. Sheldon is portrayed by Jim Parsons.
Howard Wolowitz is Bernadette Rostenkowski's husband, father of Halley Wolowitz and Neil Michael Wolowitz, and he works as an aerospace engineer at the California Institute of Technology with Leonard, Sheldon, and Raj. Howard is portrayed by Simon Helberg.
Penny Hofstadter is Leonard Hofstadter's wife, and she currently works as a pharmaceutical sales representative at Zangen with Bernadette. When she first moved in across the hall from Leonard, she was a waitress at The Cheesecake Factory and a struggling actress who had a long on again-off again relationship with Leonard. Penny is portrayed by Kaley Cuoco.
Leslie Winkle is an experimental physicist who has done research with Leonard at the California Institute of Technology. She has had brief flings with both Leonard and Howard. Leslie is portrayed by Sara Gilbert
Amy Farrah Fowler
Bernadette Wolowitz is Howard Wolowitz's wife and the mother of Halley Wolowitz and Neil Michael Wolowitz. She works at as a microbiologist at Zangen with Penny and was also once a waitress with Penny at the Cheesecake Factory. Bernadette is portrayed by Melissa Rauch.