Amy's mother (first name unknown), appeared briefly in "The Desperation Emanation" via webcam, where she spoke to Amy and met Sheldon.

As a parent, she made deals with her daughter to get her to do things. For example, in "The Robotic Manipulation", Amy says she agreed to date someone at least once a year in return for the use of her mother's George Foreman grill.

She is played by Annie O'Donnelland listed as "Mrs. Fowler" in the episode credits.