Nancy was an aunt of Leonard Hofstadter.
In "The Zazzy Substitution", Leonard mentions that his Aunt Nancy, like Sheldon, had a multitude of cats. She had dozens while Sheldon had not yet collected his first dozen. When Nancy passed away, the cats turned on her and ate her. Sheldon thought that that was a practical way to go.
- Brother or ex-brother-in-law: Alfred Hofstadter
- Sister or ex-sister-in-law: Beverly Hofstadter
- Nephews: Leonard Hofstadter, Michael Hofstadter
- Niece: Unnamed
- Niece-in-Law: Penny Hofstadter née ?
- Possible Niece-in-Law: Unnamed
- Nephew-in-Law: Unnamed
- Possible Father: Unnamed
- Possible Mother: Unnamed
- Possible Brother/Husband: Floyd
- Possible Sisters: Edna, Unnamed
- Possible Children: Unnamed