Susan (last name unknown) is the mother of Penny and wife of Wyatt. She also has two other children, one boy named Randall and a second girl who we have never met. She lives with her husband outside of Omaha, Nebraska on their small farm where they raised their three children.
She was the only mother of any members of the gang who hadn't been seen on the show for quite a long time until she finally appeared in the first episode of Season 10/208th episode "The Conjugal Conjecture", except for Stuart Bloom's mother who up to that point is only mentioned and Emily Sweeney's mother and Leslie Winkle's mother who both haven't been seen or mentioned.
In "The Flaming Spittoon Acquisition", Sheldon implies that she's fat (as well as in "The Pulled Groin Extrapolation" where he states he has seen pictures of her and sarcastically encourages Penny to keep eating) and Penny reveals that her mother smoked pot when she was pregnant with her.
In "The Transporter Malfunction", Leonard and Sheldon told Penny they didn't want to open the Star Trek Transporters she had just bought them because once you open the box, it loses its value. Penny relied, "Yeah, yeah, my mom gave me the same lecture about my virginity. I gotta tell you, it was a lot more fun when I took it out and played with it."
In "The First Pitch Insufficiency", Amy wants to know when Penny and Leonard are getting married. They haven't set a date and Penny wants to wait long enough to prove to her mother that she's not pregnant.
In "The Bachelor Party Corrosion", Penny tells her father that she eloped with Leonard. Her mother was out with Penny's brother Randall who was celebrating being sober for one month and had received his 10th chip on account of being sober for a month. Her mother was going to make her son a little necklace to commemorate the occasion.
In "The Conjugal Conjecture" Susan first appears in person where she visits California with her son and husband to attend Leonard and Penny's wedding redo and is worried about her son that is on parole and what Leonard's parents would think about them.
- Kaley Cuoco originally had stated that she would like to have Lisa Kudrow play Penny's mother; however, she was quite pleased working with her former character's mother from "8 Simple Rules".
- When Penny talks to her mother about being mother she tells her mother that she is not pregnant which was a first for their family.
- She had already met Leonard off-screen before her first appearance. This was hinted in "The Bachelor Party Corrosion" when Penny, Bernadette and Amy are discussing Penny waiting to tell her parents she got married to Leonard, Amy says "Well, it's kind of sad that they don't know. I mean, they love Leonard." referring to Wyatt and Susan.
- According to a July 2016 article on the TBBT Facebook page, actress Katey Sagal has been cast as Penny's mother, Susan, and will be seen in the Season 10 premiere. This will be a reunion of sorts for Sagal and Cuoco, who played mother and daughter on the sitcom 8 Simple Rules. Kaley has stated that Katey is her "TV mom".