In "The Rhinitis Revelation" (S05E06), Penny asks God to make her brother stop cooking methamphetamine but without involving the police when Sheldon's mother decides to get them to pray at a Roman Catholic church.
In "The Bachelor Party Corrosion " (S09E03), Penny's father tells Penny that her mother is out with her brother celebrating one month of being sober. He had also received his 10th one-month-sober chip.
It's revealed in "The Convergence-Convergence" (S09E24) that Penny's brother had been released from prison due to overcrowding, making him eligible to attend her redo wedding ceremony with the family.
In "The Conjugal Conjecture" (S10E01), Randall comes to Pasadena with his parents to attend the re-wedding, he smiles a lot and embarrasses his mother.