Zazzles is one of Sheldon Cooper's 25 cats in "The Zazzy Substitution", adopted to help Sheldon get over his and Amy's "break up". He is the only cat in the "clowder" not named after a Manhattan Project physicist. Sheldon claims Zazzles was simply too "zazzy" and he couldn't help not naming him Zazzles. His previous name was going to be Hermann von Helmholtz.
At the end of the episode, Sheldon and Amy set up a booth and pay a child $20 to take Zazzles. His actions definitely show that Sheldon is a cat person though in "The Fuzzy Boots Corollary" Sheldon discouraged Leonard from getting a cat.
- There is a good chance that Zazzles was Sheldon's favorite cat as he was given a special name and was almost always being held by him.